Project Title Potential Anthraquinone-based Antibiotics from Noni Plant
Project Category Innovation
Abstract Naturally occuring anthraquinones and their derivatives possess great therapeutic potential and pharmacological activities as antibacterial, antioxidant,anti-coagulant, anti-mutagenic, antibiotic, anti-cancer, antimicrobial, anti-inflammatory, anti-HIV and anti-leukemic agents. The functionalized coumarin derivatives possess more than one reactive group (OH, COOH) and act as monodentate, bidentate chelate, mono- and bidentate bridging ligands toward the transition metal ions. The presence of transition metals could alter the overall structure of the newly formed complex and thus can increase the affinity of the compound to DNA. The isolated bioactive anthraquinones, damnacanthal and nordamnacanthal were used as ligands to synthesize new metal complexes; Cu(II)-nordamnacanthal complex and Cu(II)- damnacanthal complex, having copper, iron and zinc as the central metal. This ability has reached an increasing interest since the therapeutic efficacy, the specific biological activity and pharmacological properties of the anthraquinone compounds were found to be improved upon complexation with metal ions. The synthesized compounds will be tested for antimicrobial activities. Cu(II)-nordamnacanthal complex and Cu(II) – damnacanthal showed stronger inhibition against all the five bacteria strains tested (Escheriachia coli, Salmonella pneumoniae, Psedomonas aeruginosa, Proteues vulgaris and Klebsiella pneumoniae). The synthesized metal complexes showed better antimicrobial activity compared to the ligands itself. Hence, we have successfully established a profile of new synthesized compounds with enhanced antimicrobial properties. The anthraquinones derivatives are known to have an important antibacterial and anti-fungal characteristic as well as there are a lot of commercially obtainable anthraquinone-based antibiotics.
Validation Status Validated
Validation Date 2020-02-29


Staff Status
Vivien Jong Yi Mian, Prof. Madya Dr. Leader
Mohammad Isa bin Mohamadin,Prof. Madya Ts. ChM. Dr. Member


Event Name Event Date Event Level Achievement Event Venue
Invention, Innovation & Design (IID) and Sarawak Invention, Innovation & Design (SIIDEx) Pre-Selection 2017 2017-07-24 Campus Participation Dewan Jubli, UiTM Sarawak