| Abstract |
Naturally occuring anthraquinones and their derivatives possess great
therapeutic potential and pharmacological activities as antibacterial,
antioxidant,anti-coagulant, anti-mutagenic, antibiotic, anti-cancer,
antimicrobial, anti-inflammatory, anti-HIV and anti-leukemic agents. The
functionalized coumarin derivatives possess more than one reactive group
(OH, COOH) and act as monodentate, bidentate chelate, mono- and
bidentate bridging ligands toward the transition metal ions. The presence of
transition metals could alter the overall structure of the newly formed complex
and thus can increase the affinity of the compound to DNA. The isolated
bioactive anthraquinones, damnacanthal and nordamnacanthal were used as
ligands to synthesize new metal complexes; Cu(II)-nordamnacanthal complex
and Cu(II)- damnacanthal complex, having copper, iron and zinc as the
central metal. This ability has reached an increasing interest since the
therapeutic efficacy, the specific biological activity and pharmacological
properties of the anthraquinone compounds were found to be improved upon
complexation with metal ions. The synthesized compounds will be tested for
antimicrobial activities. Cu(II)-nordamnacanthal complex and Cu(II) –
damnacanthal showed stronger inhibition against all the five bacteria strains
tested (Escheriachia coli, Salmonella pneumoniae, Psedomonas aeruginosa,
Proteues vulgaris and Klebsiella pneumoniae). The synthesized metal
complexes showed better antimicrobial activity compared to the ligands itself.
Hence, we have successfully established a profile of new synthesized
compounds with enhanced antimicrobial properties. The anthraquinones
derivatives are known to have an important antibacterial and anti-fungal
characteristic as well as there are a lot of commercially obtainable
anthraquinone-based antibiotics.
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